Author ORCID Identifier

Document Type


Date of Award


Degree Name

Master of Science (MS)


Computer Science

First Advisor

KC Santosh


In recent years, the utilization of graph-based deep learning has gained prominence, yet its potential in the realm of medical diagnosis remains relatively unexplored. Convolutional Neural Network (CNN) has achieved state-of-the-art performance in areas such as computer vision, particularly for grid-like data such as images. However, they require a huge dataset to achieve top level of performance and challenge arises when learning from the inherent irregular/unordered nature of physiological data. In this thesis, the research primarily focuses on abnormality screening: classification of Chest X-Ray (CXR) as Tuberculosis positive or negative, using Graph Neural Networks (GNN) that uses Region Adjacency Graphs (RAGs), and each superpixel serves as a dedicated graph node. For graph classification, provided that the different classes are distinct enough GNN often classify graphs using just the graph structures. This study delves into the inquiry of whether the incorporation of node features, such as coordinate points and pixel intensity, along with structured data representing graph can enhance the learning process. By integration of residual and concatenation structures, this methodology adeptly captures essential features and relationships among superpixels, thereby contributing to advancements in tuberculosis identification. We achieved the best performance: accuracy of 0.80 and AUC of 0.79, through the union of state-of-the-art neural network architectures and innovative graph-based representations. This work introduces a new perspective to medical image analysis.

Subject Categories

Computer Sciences


Graph Neural Networks, GNN, Region Adjacency Graphs, RAGs, Chest X-Ray

Number of Pages



University of South Dakota



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