Pterygopalatine Ganglion Blocks in Medicine: Bridging Neuromodulation and Pain Relief

Author

Tori B. Ostrand, University of South DakotaFollow

Date of Award

Spring 5-10-2025

Document Type

Honors Thesis

Department/Major

Biology

First Advisor

Brian Burrell

Second Advisor

Barbara Goodman

Third Advisor

Taylor Soderling

Keywords

Pterygopalatine ganglion, Sphenopalatine ganglion, neuromodulation, nerve blocks, chronic pain

Subject Categories

Anatomy | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment

Abstract

Chronic pain affects millions of individuals worldwide, presenting as a multifactorial condition that impacts physical, emotional, and socioeconomic well-being. Despite the availability of both pharmacological and non-pharmacological therapies, significant side effects, limited efficacy, and addiction risks drive the need for new, innovative treatments. The pterygopalatine ganglion block (PPGB) is emerging as a promising interventional approach that targets autonomic and neurogenic pathways that may be implicated in chronic pain mechanisms. This thesis reviews the neuroanatomy of the pterygopalatine ganglion, its potential role in autonomic regulation and pain mediation, and its clinical applications in treating headache syndromes such as cluster headaches and migraines. By analyzing the anatomical, physiological, and procedural aspects of PPGB, this study highlights its potential as a safer and more effective alternative to current pain management strategies.

Recommended Citation

Ostrand, Tori B., "Pterygopalatine Ganglion Blocks in Medicine: Bridging Neuromodulation and Pain Relief" (2025). Honors Thesis. 364.
https://red.library.usd.edu/honors-thesis/364