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Dentin hypersensitivity, which causes sensitive teeth, is a heavily explored area in dental health research. Thousands of natural tiny tubules in dentin connect dental pulp and biomaterials applied to the oral side of the tooth. Mimicking and maintaining a suitable environment by the dentin surface is very important to study the function and safety of biomaterials and the oral microbiome. This research study is focused on designing a dentin slice integrated microfluidic device which mimics the pulp side and the cavity side of dentin or any dentin area exposed to the oral cavity. This device is manufactured from two plasma bonded polydimethylsiloxane (PDMS) pieces, which are produced in a newly designed 3D printed PLA mold. Further, my research will be aimed at studying Streptococcus mutan bacteria, oral biofilms, and its response to antibacterial biomaterials (such as nontoxic L-arginine), dentinal tubule occlusion by antibacterial biomaterials (such as based on alginate), Penetration of proteins through dentin tubules using the new dentin integrated microfluidic device. The possibility of an influenza virus penetrating through dentin tubules and the application of the device to the field of colorectal cancer research will also be discussed.

First Advisor

Grigoriy Sereda

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