Document Type


Date of Award


Degree Name

Master of Science (MS)



First Advisor

Dr. Grigoriy Sereda


This study focuses on the development of non-toxic dental materials that can adhere to dentin, occlude dentinal tubules, and release a drug with or without biological triggers. The properties of those materials are examined by SEM, UV-vis absorption spectroscopy, and a fluoride-selective electrode. The study also investigates the surface modification of calcium carbonate surface with casein, which stabilizes its micro-and nanoparticles in aqueous suspensions, making them suitable for use in dentifrices. The results indicate that the morphology and composition of the particles affect their ability to hold and release eugenol, with the casein-coated calcium carbonate microspheres being the most acid-sensitive and promising for use in dentifrices. Furthermore, the study demonstrates that the novel materials can release eugenol or (and) fluoride under physiologically low pH conditions, regardless of the presence of other ingredients in artificial saliva, thereby maintaining bulk fluoride concentration comparable to most fluorinated kinds of toothpaste. Low pH-triggered release mechanisms selectively supply drugs to the areas that need them the most, reducing the overall dose and ushering in a new era of targeted dentifrices. Overall, the study provides valuable insights into the development of safe and effective dental materials that can enhance oral health care by adhering to teeth, occluding tubules, and releasing drugs selectively to the areas that need them the most.

Subject Categories



Calcium Carbonate, Dentin, Drug Delivery, Eugenol, Fluoride, Microparticles

Number of Pages



University of South Dakota

Included in

Chemistry Commons



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